https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45179 Wed 26 Oct 2022 19:26:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52404 Wed 11 Oct 2023 11:52:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29617 n = 20 females, n = 22 males). OPS videomicroscopy (Microscan) was used to view ear conch skin microcirculation at 6, 24, and 72 h of age. Stored video was analyzed by a masked observer using proprietary software. There were no significant differences between the sexes for any structural parameters at any time point. There was a significant increase over time in small vessel perfusion in female infants only (P = 0.009). A number of 6- and 72-h measurements were significantly correlated, but differed from the 24-h values. These observations confirm the utility of the ear conch for neonatal microvascular videomicroscopy. They provide a baseline for studies into the use of OPS videomicroscopy in infants. The changes observed are comparable with previous studies of term infants using these and other microvascular techniques. It is recommended that studies for examining the mature neonatal microvascular structure be delayed until 72 h of life, but studies of the physiology of cardiovascular transition should include the 24-h time point after delivery.]]> Wed 11 Apr 2018 16:42:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26761 Wed 11 Apr 2018 15:56:38 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16581 Wed 11 Apr 2018 14:11:56 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27351 Wed 11 Apr 2018 13:32:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16521 Wed 11 Apr 2018 10:55:59 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25894 Wed 11 Apr 2018 09:33:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36967 28 weeks) and kidney function in infants, <2.5 years of age, from the Gomeroi gaaynggal cohort. Pre‐pregnancy body mass index (BMI) was recorded at the first prenatal visit and maternal adiposity indicators (percent body fat and visceral fat area) measured at >28 weeks gestation by bioelectrical impedance analysis. Fetal kidney structure was assessed by ultrasound. Renal function indicators (urinary albumin:creatinine and protein:creatinine) were measured in infants from a spot urine collection from nappies. Multiple linear regression and multi‐level mixed effects linear regression models with clustering were used to account for repeated measures of urine. 147 mother–child pairs were examined. Estimated fetal weight (EFW), but not fetal kidney size, was positively associated with maternal adiposity and pre‐pregnancy BMI. When adjusted for smoking, combined kidney volume relative to EFW was negatively associated with maternal percentage body fat. Infant kidney function was not influenced by maternal adiposity and pre‐pregnancy BMI (n = 84 observations). Current findings show that Indigenous babies born to obese mothers have reduced kidney size relative to EFW. We suggest that these babies are experiencing a degree of glomerular hyperfiltration in utero, and therefore are at risk of developing CKD in later life, especially if their propensity for obesity is maintained. Although no impact on renal function was observed at <2.5 years of age, long‐term follow‐up of offspring is required to evaluate potential later life impacts.]]> Mon 26 Aug 2024 12:46:21 AEST ]]>